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Follow-up studies

When warranted, ERBC conducts follow-up and supplemental safety pharmacology studies. These studies allow to investigate the mechanism of adverse effects suspected and/or observed through the core battery or the clinical trials programs and/or to evaluate potential adverse pharmacodynamic effects on organ system functions not addressed by the core battery or repeated dose toxicity studies.

  • Cardiac output
  • Ventricular contractility
  • Vascular resistance
  • Effects of endogenous or exogenous substances on the cardiovascular responses
  • Airway resistance
  • Compliance
  • Pulmonary arterial pressure
  • Blood gases and blood pH
  • Behavioral pharmacology
  • Learning and memory
  • Ligand-specific binding
  • Neurochemistry
  • Visual, auditory and/or electrophysiology examinations
  • Ligand-specific binding
  • Functional response to agonists or antagonists
  • Diuresis, osmolality and pH in rat
  • Fluid/electrolyte balance in rat
  • Plasma proteins, cytology and blood chemistry in rat


  • Gastric secretion in rat
  • Gastric damage (ulcerogenic potential in mouse)
  • Gastrointestinal motility (charcoal meal propulsion in mouse)


  • ERBC investigates on a routine basis the effects of new therapies on immune, endocrine and hepatic functions (including the appearance of liver damages).
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Therapeutic areas

Cardiology

Neurology

Pneumology

Oncology

Immuno-oncology

Allergy

Dermatology

Gastro-enterology

Analgesia/inflammation

Endocrinology

Haematology

Nephrology

A comprehensive range of preclinical models for short and long-term toxicology studies

Our animal models

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Mouse

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Rat

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Dog

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Rabbit

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Ferret

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Cynomolgus Monkeys

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Guinea Pig

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Cat

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Hamster

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A wide range of services that span the entire drug discovery and development continuum and can be tailored to specific research conditions

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Each project is managed by a study director, relying on a multi-disciplinary team of experts.