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PK/PD & Metabolism

To support preclinical and clinical development programs, ERBC conducts PK-PD and metabolism studies on pharmaceuticals and biotechnology based products.

Conducted in a broad range of administration routes, dosing regimens and animal species, these studies are managed by senior scientists with deep expertise in biology, pharmacology, data analytics and regulatory.

Pharmacokinetic - bioavailability

  • Species: rat, mouse, rabbit, dog, minipig, marmoset
  • All administration routes
  • Analysis of biological samples (plasma, urine, tissues…)

Pharmacodynamic in vivo and in vitro

  • Deep expertise in human recombinant proteins, notably GSCF, hGH and EPO (in vivo)

In vitro metabolism

  • Evaluation of metabolism using liver metabolic fractions (S9, microsomes)
  • Evaluation of metabolism using hepatocytes
  • Metabolite profiling, identification and quantification
  • CYP phenotyping assay
  • CYP induction in human hepatocytes
  • CYP inhibition in human liver microsomes
  • Time dependent CYP inhibition in human liver microsomes

Skin Penetration Study

  • In vitro Skin Absorption (OECD 428) 

Histochemical and immunohistochemical determinations in tissues

  • Cytochrome p450
  • Glutathion S-transferase
  • γ-Glutamyl transpeptidase
  • Cytochrome oxidase
  • Adenosine triphosphatase
  • Glucose-6-phosphate dehydrogenase
our expertise by

Therapeutic areas

Cardiology

Neurology

Pneumology

Oncology

Immuno-oncology

Allergy

Dermatology

Gastro-enterology

Analgesia/inflammation

Endocrinology

Haematology

Nephrology

A comprehensive range of preclinical models for short and long-term toxicology studies

Our animal models

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Mouse

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Rat

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Dog

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Rabbit

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Marmoset

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Ferret

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Cynomolgus Monkeys

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Guinea Pig

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Cat

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Hamster

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MiniPig

A wide range of services that span the entire drug discovery and development continuum and can be tailored to specific research conditions

Our Services

NEED TO CREATE YOUR

UNIQUE PROJECT

Each project is managed by a study director, relying on a multi-disciplinary team of experts.