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In vitro toxicology

In vitro toxicology has progressed hugely over the past decades and is now seen as a science in itself. In line with the 3Rs concept, ERBC performs ICH and OECD compliant tests to identify toxicology events in nonwhole animal models (cell cultures, 3D models…).

Rapid, reproducible and cost-effective, these assays contribute to enhance R&D productivity and minimize the use of animals.

  • Membrane barrier test method for skin corrosion (Corrositex®)
  • Human skin model test (Episkin™)
  • Human skin model test (Episkin™)
  • Balb/C 3T3 neutral red uptake
  • Balb/C 3T3 cell phototoxicity assay (neutral red uptake)
  • Test by direct or indirect contact in clone 929, Balb/C 3T3, V79
  • Cell proliferation and migration in primary normal human keratinocytes
  • Cytotoxicity in primary rat hepatocytes
  • HepG2 cell screening test
  • LLC-RK1 cell screening test
  • Colony forming unit granulocyte/macrophage assay
  • Red blood cell haemolysis test

Endpoints

  • Mitochondrial Reductase Activity (MTT Staining)
  • Sulforhodamine B Uptake

Cell line panels

  • Non-Small Cell Lung Cancer (NSCLC): A549, NCI-H23, NCI-H460
  • Colon cancer: HCT-116, HT29, SW-620
  • Ovarian cancer: OVCAR-3, SK-OV-3
  • Prostate cancer: PC-3, DU-145
  • Breast tumor: MCF7, MDA-MB-231, HS 578T
our expertise by

Therapeutic areas

Cardiology

Neurology

Pneumology

Oncology

Immuno-oncology

Allergy

Dermatology

Gastro-enterology

Analgesia/inflammation

Endocrinology

Haematology

Nephrology

A comprehensive range of preclinical models for short and long-term toxicology studies

Our animal models

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Mouse

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Rat

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Dog

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Rabbit

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Marmoset

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Ferret

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Cynomolgus Monkeys

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Guinea Pig

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Cat

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Hamster

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MiniPig

A wide range of services that span the entire drug discovery and development continuum and can be tailored to specific research conditions

Our Services

NEED TO CREATE YOUR

UNIQUE PROJECT

Each project is managed by a study director, relying on a multi-disciplinary team of experts.