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Local tolerance

Non-clinical local tolerance testing is intended to support human exposure to a compound (both active substance and excipients) at contact sites of the body. Local tolerance testing should be conducted initially in support of clinical trials, but also later on to support a final product.

ERBC performs local tolerance testing in a number of animal models, using a large panel of administration routes. All studies are designed to distinguish any physical consequences of administration (e.g. local trauma following injection, or purely physicochemical actions of the compound) from local toxicological or pharmacodynamic effects.

  • Dermal (rat, rabbit, minipig)
  • Intra-articular (rabbit, minipig)
  • Intramuscular (all species)
  • Intranasal (rat, rabbit, dog)
  • Ocular (rabbit, dog, minipig)
  • Buccal (Syrian hamster)
  • Subcutaneous (all species)
  • Intravaginal (rat, rabbit, dog)
  • Intrarectal (rat, rabbit, dog)
  • Paravenous, intra-arterial and intravenous (rabbit - single dose only)
  • Intravesical (rat, minipig)
  • Intra-articular (rabbit, minipig)
  • Subcutaneous (all species)
our expertise by

Therapeutic areas

Cardiology

Neurology

Pneumology

Oncology

Immuno-oncology

Allergy

Dermatology

Gastro-enterology

Analgesia/inflammation

Endocrinology

Haematology

Nephrology

A comprehensive range of preclinical models for short and long-term toxicology studies

Our animal models

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Mouse

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Rat

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Dog

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Rabbit

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Marmoset

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Ferret

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Cynomolgus Monkeys

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Guinea Pig

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Cat

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Hamster

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MiniPig

A wide range of services that span the entire drug discovery and development continuum and can be tailored to specific research conditions

Our Services

NEED TO CREATE YOUR

UNIQUE PROJECT

Each project is managed by a study director, relying on a multi-disciplinary team of experts.