Non-clinical local tolerance testing is intended to support human exposure to a compound (both active substance and excipients) at contact sites of the body. Local tolerance testing should be conducted initially in support of clinical trials, but also later on to support a final product.
ERBC performs local tolerance testing in a number of animal models, using a large panel of administration routes. All studies are designed to distinguish any physical consequences of administration (e.g. local trauma following injection, or purely physicochemical actions of the compound) from local toxicological or pharmacodynamic effects.