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Immunotoxicology

Toxicity to the immune system encompasses a variety of adverse events, including the ability of a compound to override the immune system and cause an allergic reaction, or to impair the immune functions required by the host to defend itself against infectious or neoplastic disease. To comply with regulatory authorities, all new human pharmaceuticals and chemicals need to be evaluated for their potential to produce immunotoxicity. With the explosion of immunomodulatory biopharmaceuticals and small molecules developed for the treatment of cancers and inflammation, the understanding of fundamental immunology has significantly progressed and has opened the possibility to finely evaluate and characterize an immune response.

Relying on the extensive expertise in immunology of its analytics lab, ERBC performs a number of assays to predict the range of potential immune-toxicological consequences of a given compound.

  • Delayed dermal sensitization study in guinea pig
    • Magnusson and Kligman tests
    • Buehler test
  • Local lymph node assay
  • Active anaphylaxis study
    • Species: guinea pig
  • Passive anaphylaxis study
    • Species: Mouse, Rat, Guinea Pig
  • Immunogenicity assessment in animal and human samples by validated methods
  • Tier I assays (usually included in standard regulatory studies to detect immunosuppressive effects)
    • White blood cell differential count
    • Globulin levels and A/G ratios
    • Lymphoid organ weight
    • Lymphoid tissue histopathology
    • T-Cell Dependent Antigen Response (TDAR)
    • Plaque Forming Cell Assay (PFC)
    • Anti-KLH IgM ELISA test
    • Lymphocytes sub-set FACS analysis

our expertise by

Therapeutic areas

Cardiology

Neurology

Pneumology

Oncology

Immuno-oncology

Allergy

Dermatology

Gastro-enterology

Analgesia/inflammation

Endocrinology

Haematology

Nephrology

A comprehensive range of preclinical models for short and long-term toxicology studies

Our animal models

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Mouse

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Rat

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Dog

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Rabbit

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Marmoset

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Ferret

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Cynomolgus Monkeys

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Guinea Pig

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Cat

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Hamster

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MiniPig

A wide range of services that span the entire drug discovery and development continuum and can be tailored to specific research conditions

Our Services

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UNIQUE PROJECT

Each project is managed by a study director, relying on a multi-disciplinary team of experts.