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Developmental & reproductive toxicology

Pharmaceuticals and chemicals have sometimes unanticipated and complex impacts on reproductive capacity and/or embryonic development: they can affect sexual function and fertility in adult males and females or lead to malformations, developmental retardations or mortality of the fetus when pregnant women are exposed. Over the past 30 years, fundamental understanding of embryogenesis and mechanisms of developmental toxicity have greatly advanced as well as the regulatory framework of the developmental and reproductive toxicology (DART) studies.

ERBC’ scientists have extensive experience in DART conducting a broad range of ICH and OECD-based studies in rodents and rabbits as well as advanced investigations in rats. They have implemented a historical control database to ensure accuracy and reproducibility of ERBC test results and develop next generation testing approaches that support the 3R principles.

ICH-based studies

All studies presented below can include toxicokinetic analysis

  • Species: rat (only females, only males, both sexes)
  • Administration routes: oral, subcutaneous, intravenous (by bolus or continuous infusion), intravaginal, intraperitoneal (at an appropriate dose regimen)
  • Species: rat, rabbit, mouse
  • Administration routes: oral, subcutaneous, dermal, intravenous (by bolus or continuous infusion only in rat and rabbit), intravaginal, intraperitoneal (at an appropriate dose regimen)
  • Species: rat
  • Administration routes: oral, subcutaneous, intravenous (by bolus or continuous infusion), intravaginal, intraperitoneal (at an appropriate dose regimen)
  • Species: rat
  • Administration routes: oral, subcutaneous, intravenous (by bolus), intraperitoneal (at an appropriate dose regimen)

OECD-based studies

  • Species: rat, rabbit
  • Limit test or full test
  • Administration route: oral

  • Species: rat
  • Administration route: oral
  • Species: rat
  • Administration route: oral
  • Species: rat
  • Administration route: oral

Additional studies

  • Species: rat
  • Administration route: oral
our expertise by

Therapeutic areas

Cardiology

Neurology

Pneumology

Oncology

Immuno-oncology

Allergy

Dermatology

Gastro-enterology

Analgesia/inflammation

Endocrinology

Haematology

Nephrology

A comprehensive range of preclinical models for short and long-term toxicology studies

Our animal models

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Mouse

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Rat

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Dog

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Rabbit

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Marmoset

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Ferret

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Cynomolgus Monkeys

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Guinea Pig

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Cat

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Hamster

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MiniPig

A wide range of services that span the entire drug discovery and development continuum and can be tailored to specific research conditions

Our Services

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UNIQUE PROJECT

Each project is managed by a study director, relying on a multi-disciplinary team of experts.