Pharmaceuticals and chemicals have sometimes unanticipated and complex impacts on reproductive capacity and/or embryonic development: they can affect sexual function and fertility in adult males and females or lead to malformations, developmental retardations or mortality of the fetus when pregnant women are exposed. Over the past 30 years, fundamental understanding of embryogenesis and mechanisms of developmental toxicity have greatly advanced as well as the regulatory framework of the developmental and reproductive toxicology (DART) studies.

ERBC’ scientists have extensive experience in DART conducting a broad range of ICH and OECD-based studies in rodents and rabbits as well as advanced investigations in rats. They have implemented a historical control database to ensure accuracy and reproducibility of ERBC test results and develop next generation testing approaches that support the 3R principles.

ICH-based studies

All studies presented below can include toxicokinetic analysis

OECD-based studies

Additional studies