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Analytical chemistry

Combining strong scientific and regulatory knowledge with state-of-the art technologies, the ERBC’s analytical chemistry team conducts feasibility studies and set-up and validates new testing methods. All studies are performed in a GLP facility and clinical study samples are managed in agreement with GCP requirements (FDA and EMA guidelines).

Preclinical and clinical samples analysis

  • Including logistical services

Method development/transfer and validation

  • Solid phase extraction, liquid/liquid extraction, protein precipitation plate, ultra-centrifugation and micro dialysis

Microsampling plasma/blood

  • Dried blood spot, volumetric blood micro extraction (VAMS), capillary micro sampling

Formulation and stability analysis

  • Solutions, suspensions, diet

PK/TK samples analysis

  • All biological fluids and tissues

Metabolite stability assays and identification

  • High Resolution Mass Spectrometry

Oxidative metabolism

Drug- Drug Interaction studies

  • Cytochrome P450 direct inhibition
  • Cytochrome P450 time dependent inhibition
  • Cytochrome P450 induction

Protein binding studies

Antibody studies

  • PK/TK studies
  • DAR characterization of ADC

Skin absorption studies (OECD 428)

Analysis of Veterinary Residues in Animal Tissues

  • Solid phase and liquid-liquid extraction, protein precipitation plate


Instrumentation (GLP and GXP compliant):

  • High Resolution Triple TOF mass spectrometers with MicroLC (API 6600 plus, API 5600 plus)
  • Low Resolution Triple Quadrupole mass spectrometers with MicroLC (2 API 2000, API 4000, API 4000QTrap, API 5500 QTrap)
  • HPLC equipped with UV, fluorimeter and light scattering detectors
  • UPLC equipped with UV and fluorimeter detectors
  • UV/Vis spectrophotometer
  • GC equipped with FID, NPD, ECD and MS detector
our expertise by

Therapeutic areas

Cardiology

Neurology

Pneumology

Oncology

Immuno-oncology

Allergy

Dermatology

Gastro-enterology

Analgesia/inflammation

Endocrinology

Haematology

Nephrology

A comprehensive range of preclinical models for short and long-term toxicology studies

Our animal models

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Mouse

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Rat

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Dog

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Rabbit

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Marmoset

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Ferret

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Cynomolgus Monkeys

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Guinea Pig

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Cat

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Hamster

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MiniPig

A wide range of services that span the entire drug discovery and development continuum and can be tailored to specific research conditions

Our Services

NEED TO CREATE YOUR

UNIQUE PROJECT

Each project is managed by a study director, relying on a multi-disciplinary team of experts.